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Femara reduces the amount of oestrogen by blocking an enzyme (“aromatase”) involved in the production of oestrogens and therefore may block the growth of breast cancer that needs oestrogens to grow. Nolvadex can deal with the problem right away while an aromatase inhibitor like Arimidex can work for the long-term results as it reduces the production of estrogen. Nitric oxide is not actually supplemented (it has a half-life of a few seconds), but instead supplements that stimulate the enzyme that makes nitric oxide are used. AAS use by a pregnant woman can cause pseudohermaphroditism or virilization in the female fetus or may even cause fetal death. Letrozole inhibits the aromatase enzyme by competitively binding to the heme of the cytochrome P450 subunit of the enzyme, resulting in a reduction of estrogen biosynthesis in all tissues.
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